Ancillary Studies

Although the main goal of VITAL is to test whether vitamin D or omega-3 fatty acids can prevent cancer, heart disease, and stroke, we will also assess whether these supplements confer other health benefits, such as lowering the risk for:

• diabetes
• high blood pressure
• memory loss or cognitive decline
• autoimmune conditions such as thyroid disease, rheumatoid arthritis, and lupus
• physical disability and falls
• bone fractures
• anemia
• eye problems such as macular degeneration and dry eye syndrome
• infections
• asthma
• depression
• diabetes-related kidney disease
• impaired kidney function in people with high blood pressure
• chronic knee pain symptoms
• atrial fibrillation

In addition, participants who live within driving distance of Brigham and Women's Hospital in Boston, Massachusetts have been invited for optional clinic visits to have more detailed studies, including tests of blood sugar, lung function, physical function, bone density, and heart structure.